ABT 724 trihydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ABT 724 triHClide 是一种有效的选择性 D4 受体激动剂（EC50 分别 = 12.4 nM、14.3 nM 和 23.2 nM）。

ABT 724 trihydrochloride is an effective and selective agonist of the D4 receptor (EC50 = 12.4 nM, 14.3 nM, and 23.2 nM for human, rat and ferret, respectively). ABT-724 trihydrochloride can be used in erectile dysfunction studies.(In Vitro):A weak affinity to 5-HT1A receptors (Ki = 2780 nM) is observed. ABT 724 trihydrochloride(10 μM) exhibits a selective biochemical profile, as indicated by a lack of binding affinity for >70 neurotransmitter/uptake/ion channels including D2, D3, or D5 receptors. ABT 724 trihydrochloride(10 μM) does not inhibit the PDE activity of PDE1, PDE5, or PDE6.(In Vivo):In male adult Wistar rats, ABT 724 trihydrochloride (8.8 μg/kg; s.c.) treatment facilitated penile erection in a dose-dependent manner.

ABT-724 exhibits a selective biochemical profile, as indicates by a lack of binding affinity for >70 neurotransmitter/uptake/ion channels including D2, D3, or D5 receptors up to a 10 μM concentration. A weak affinity to 5-HT1A receptors (Ki = 2780 nM) is observed. ABT-724 does not inhibit the PDE activity of PDE1, PDE5, or PDE6 at 10 μM concentrations.

ABT-724 (8.8 μg/kg; subcutaneous injection; daily; for 5 days; male adult Wistar rats) treatment dose-dependently facilitates penile erection when given s.c. to conscious rats. Animal Model:Male adult Wistar rats (~300 g) Dosage:8.8 μg/kg Administration:Subcutaneous injection; daily; for 5 days Result:Dose-dependently facilitated penile erection.

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GPCR/G Protein

Dopamine Receptor

M4 mAChR

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587870-77-7

402.7

C17H22Cl3N5

>98% (HPLC)

In Vitro:?H2O : ≥ 100 mg/mL (248.29 mM))

C1CN(CCN1CC2=NC3=CC=CC=C3N2)C4=CC=CC=N4.Cl.Cl.Cl

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(-20℃)

With Ice Pack

≥ 2 years